Researchers at the University of California, San Diego School of Medicine have launched a phase 1 human clinical trial to assess the safety and efficacy of a new monoclonal antibody for patients with chronic lymphocytic leukemia (CLL), the most common form of blood cancer in adults.
The new antibody targets ROR1, a protein used by embryonic cells during early development and exploited by cancer cells to promote tumor growth and metastasis, the latter responsible for 90 percent of all cancer-related deaths.
Because ROR1 is not expressed by normal adult cells, scientists believe it is a biomarker of cancer cells in general and cancer stem cells in particular. Because it appears to drive tumor growth and disease spread, they believe it also presents an excellent target for anti-cancer therapy.
Developed at UC San Diego Moores Cancer Center by Thomas Kipps, MD, PhD, who holds the Evelyn and Edwin Tasch Chair in Cancer Research, and colleagues, the antibody is called cirmtuzumab (also known as UC-961). In previous animal studies, Kipps’ team reported that ROR1 is singularly expressed on CLL and also on a variety of different cancers, including cancers of the breast, pancreas, colon, lung and ovary. In mouse models of CLL, ROR1 acts as an accelerant when combined with another oncogene to produce a faster-growing, more aggressive cancer.
Cirmtuzumab was developed under the auspices of the California Institute for Regenerative Medicine’s HALT leukemia grant awarded to Dennis Carson, MD, principal investigator, and Catriona Jamieson, MD, PhD, co-principal investigator to develop six distinct therapies against cancer stem cells. Kipps led one of the six projects and generated antibodies against ROR1, leading to the cirmtuzumab trial in patients with CLL.
“The primary goal of this phase I clinical trial is to evaluate whether cirmtuzumab is a safe and well-tolerated cancer stem cell-targeted agent in patients with CLL,” said Jamieson, chief of the Division of Regenerative Medicine, associate professor of medicine, director of stem cell research at UC San Diego Moores Cancer Center, deputy director of the Sanford Stem Cell Clinical Center and a principal investigator of the cirmtuzumab clinical trial.
Michael Choi, MD, assistant clinical professor of medicine and co-principal investigator of the clinical trial said, “The trial will involve patients with relapsed or refractory CLL, who will receive an intravenous infusion every 14 days at Moores, followed by regular monitoring and clinic visits to assess efficacy and identify and manage any adverse effects. Initial treatment is planned for two months.”
To learn more about eligibility for this clinical trial, call Reilly L. Kidwell at 858-534-4801 or Samuel Zhang at 858-534-8127.
We say “fuck cancer” here a lot. This might actually do it.
I’m a big, big fan of Apple products, but I’ll be skipping the watch. In fact, I’d been thinking about treating myself to a new analog watch this fall/winter (hi, Robin) and seeing the Apple watch makes me want a real one even more for some reason.
The next week is impossibly overscheduled, even by my ludicrous standards. Some good (recording studio!), some less so (the Jerz). The main bummer is that I won’t be around for the kids’ bedtimes 6 of the next 8 nights. This sucks for everyone involved.
I’m running in my first-ever organized 5K next Sunday. See previous point re: the state of my training. Ruh-roh, Raggy.
When I see that Tumblr Savior has blocked a recommended post and it’s also by a user I’ve likewise blocked, I stand right up and high-five myself. (If you are reading this, you are not blocked.) ((You guys would probably be pretty surprised by who is.)) (((Nope, never gonna tell.)))
Will one of you please drive me home? I’d prefer to have a big glass of bourbon and maybe a nap in the back seat. Msg me for deets. Thx.
1. Go to http://www.fcc.gov/comments 2. Click on 14-28 3. Comment “I want internet service providers classified as common carriers.” 4. Done
As we go through round N of the net neutrality fight, the phrase that pays is “common carriers.” That’s the same status that the phone companies had. It forces them to be completely agnostic about the content they carry, and just shut up and carry it.
Do this, and use that phrase when you talk to your whoevers in DC.
I can’t decide if it’s a feature or a bug that observing the socially correct minimum horizontal following distance on an escalator puts your face at someone’s exact butt level.
Something fierce, huge, and venomous has bitten my shin at a point where every nerve ending in my body apparently meets, a spot where there is coincidentally no muscle and not a lot of skin atop the bone, and I cannot express to you how much I want to blowtorch my own limb right now, jeebus, make it STOP.
Speaking of setting myself on fire, I’m car shopping right now. Worst first world problem? Worst first world problem.
After waiting far too long, I was finally stirred to action early this morning on a difficult-but-right thing to do, and then promptly thwarted by bureaucrats. I’m not done, though. (STM, kinda.)
What’s missing in a person’s life that leads them to be a self-described fan boi/grrl of a company that makes consumer electronics? And then drives that person to spend the day on twitter hammering the products and fan boiz/grrlz of competing consumer electronics companies?
I’m traveling to the Jerz for two days next week. Never been except for driving across, to and from NYC. I’m planning to dress, style my hair, and speak exactly like Paulie Walnuts to fit in better.
Belly fat, pattern baldness, lumbar discs, overactive maxillofacial nerves, early knee and shoulder obsolescence due to design flaws, tissue that inflames for no apparent reason. Engineering failures across the board. If I’d bought this contraption, I’d want a refund.
On that same thread: as has happened so many times before, just as I was making serious momentum on a fitness regimen, this wretched body decided to repay me with a massive bronchial infection that leaves me winded going up the stairs. After this likely 2-week+ setback I’ll get to start all over again. If I choose to bother.
I have listened to that a cappella thing I reblogged this morning a dozen times. It’s silly, maybe, but that kind of human achievement (the writing, the arrangement, the performances!) gets very close to what I consider spiritual. “Why we’re here”-level stuff. What we can do when all the lower tiers of the Maslow are fulfilled. And that leads to thoughts on why it’s so fucking important that everyone’s basic needs are taken care of. (Longer post on that, someday.)
I have overscheduled my September. Bad choice. As if it wasn’t bad enough that we are losing like 40 minutes of light every day, I went and did this to myself. Not helping.
The lighting tech (an A/V Club dropout, resplendent in a too-small black tee that said SECURITY and a scraggly beard that reached to his nipples) for a popular Quad Cities cover band called Cheeze Pizza (most notable for their fifty-something lead singer dressing in drag) tried to upstage us, then committed a heinous etiquette breach by starting to set up his shit 10 seconds after we finished, rendering me one more shoulder bump from committing a gruesome onstage homicide-by-lighting-truss-rectal-insertion.
Two friends—one dear, the other more of a FOAF—who I used to think were sensitive and intelligent have lived in close company with small-minded idiots for too long, and the effects are heartbreaking to see. Choose your companions wisely.
The backlash against the date-rape-drug-detecting nail polish baffles me. OF COURSE the priority is educating men and raising boys to end rape culture. Obviously. In this house we are working hard to raise our son exactly that way. HOWEVER, until the rest of the world catches up, and that may take a while, I want my daughter to have every possible tool at her disposal to protect herself. If this sort of thing saves even one woman, how is it bad? We can play offense and defense at the same time, and we should.
One Direction is pläying at Soldier Field tonight and there is a 60% chance of thunderstorms. Team Cloud!
I heard that the dev team at my previous employer was instructed six weeks ago to stop writing software. Due to the company being sold, TPTB didn’t want to risk any release-related production outages. So those engineers have been working short hours, surfing the web, looking for new jobs, etc. Fuck yeah, capital markets!
Bad At Marketing, Part CLXXVI: I’ll be playing with The Recliners again at Poopy’s in Savanna, IL this Sunday from 1-5. It’s the last big outdoor show of the season….come on out, maybe see one of your favorite farmers from northwest Illinois.
I got a big whiff of the river this morning and it smelled like the lake.
That shouldn’t be unusual. We turned that river around so the lake flows into it. The river literally is the lake. But it is unusual, at least at the Van Buren bridge, a couple of miles downriver from the mouth. It’s an unmistakeable smell, and there it was, strong and…green? Something.
My nose is easily my poorest input device, and that’s even after 35 years of constant, high wattage abuse to my ears. When people ask me, “do you smell that?” the answer is always no. Gas? Weed? Skunk? Farts? Nope. It’s a good thing we’re generally past the point where the species needs that skill to identify rotten food or predator danger in the wild. This otherwise functional and occasionally interesting line of genes would have ended long ago.
This morning, anyway, oddly, my snoot worked. I smelled that lake just as sure as I was standing in it the summer before kindergarten, trying to catch minnows with a butterfly net. It’s hard for me to distinguish the components of that smell, much as I suppose it would be hard for a deaf man to pick out the viola line at the symphony. From what I know, that signature smell is probably due to a certain set of algae or bacteria. That sounds bad, but it’s pleasant, I promise. And not just from the associated warm memories. I’ve had some rough days by that lake, too, and the smell registered just the same. It’s distinct. I don’t recall any other lake, Great or otherwise, smelling that way, either. It’s a healthy, living smell.
Like it came, so it left. Curious, at lunchtime I went back out there to see if I might find it again, but I couldn’t. Nor was it there when I crossed that bridge again on my way home. Maybe the wind shifted, or maybe it’s one of those things you can only find when you aren’t looking.
I’ve been listening a lot to The 2nd Law lately (skipping past the dubstep nonsense, of course). It’s incredible, really. Like Queen on anabolic steroids. Matthew Bellamy’s voice stuns and amazes me.
And I don’t know a lot about his background as a songwriter, but listening to this, it seems pretty clear he was classically trained and is a particular fan of Romantic composers. I hear Rachmaninoff and Liszt. It’s lovely.
Giving mice common intestinal bacteria eliminated peanut allergies
Truth: the next major wave of medical advances will be in understanding the role and workings of the microbiome, and it’s starting now. When we look back in 25 years, it’s going to be every bit as big as the discovery of antibiotics, the development of vaccines, and genetic medicine.
Hey locals, I did a completely shitty job marketing this, but my band The Recliners is playing tomorrow from 3:00-5:00pm at Durty Nellie’s in Palatine. It’s an all-ages show, and proceeds go to the American Cancer Society. Special bonus: we are shooting a video. Yes, you will probably see clips of it here, eventually, but wouldn’t you rather be able to say you were there?
I golfed today. Quite well, actually. But I won’t talk about it at all because I know the only thing people care less about than your dreams is your golf game.
You may be aware that I think a lot. (Way too much, really.) I’ve realized that when I’m thinking while driving alone, and a thought enters my head that is especially negative, I reflexively change the radio station, even if a song I like is playing. It’s like some part my brain is crying out to change the path the other part is on.
I stopped by Mom and Dad’s house on the way home from the golf course to “fix” their TV. I changed the input from “HDMI 2” to “CABLE.” Move it on over, Dumbledore: I am the baddest wizard of all time.
We’ve had a fairly relaxed, stress-free few weeks around here. It’s been nice. But that’s ending; the kids go back to school Monday, including Danny starting at middle school, which is utterly, preposterously too soon for any 10-year-old, never mind those with anxiety issues. Please keep a good thought, if you would.
Last night I was watching Fallon and wondering, “who’s the white guy with the guitar, sitting in with The Roots?” Then going to or coming out of a break, he sang a song I kind of recognized, and another, then another. Dim memories; not clear “oh, yeah, that!” but clearly something that had imprinted on me somewhere in the foggy past.
Later, Jimmy said he is Tom Bailey, lead singer of Thompson Twins. I can be forgiven for not recognizing him. His look has changed a little. And, frankly, I was never a big consumer of his work. I am very much on the record as having a different view of “80s music” than what is modal in popular culture. I have my preferences, and they are not…this.
But god dammit if this guy didn’t plant hooks in my head 30 years ago that, even after zero exposure in the interim, are still rattling around up there somewhere. I have to give credit where it’s due: this is fine pop songcraft, the dude can really sing, and the warmth of those synth tones could cleave glaciers.
And if he’s good enough for the freaking Roots, he has earned another listen from me, for sure.
“School is out for many Ferguson students, but teachers are still holding classes at local public libraries. On Tuesday, teachers stood outside of Ferguson Public Library holding signs that said “here to teach” and “students welcome.” Inside the library, teachers helped students with reading, science, art and math. “We’re trying to provide a positive and productive place for students,” said Ferguson-Florissant art teacher Carrie Pace to local outlet the Riverfront Times. “A place for them to come and do something educational and meet up with other students.” One 16-year-old student, Derrick Washington, came to the library to help tutor students younger than him, like his brother. He spoke with Huffington Post reporter Ryan J. Reilly about the experience. “While they’re not in school, I can help them get ready for school,” said Washington, who is a high school student in the Ferguson-Florissant district. “Keep them in line … keep them from getting in trouble.””—
No one wants to fight with their racist cousin on Facebook. They’d rather poop out their frustration on twitter (like I did). On tumblr, some people just don’t have more than 140 character rants (that’s me again) and feel unable to express themselves
I’m not sure which I like less: the idea that Facebook is censoring us, or that we are self-censoring. And both are probably true. Ugh.